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NRF2 plays a critical role in this process by upregulating the expression of genes involved in the synthesis of -GC, thereby increasing the overall production of GSH [34]

The GH pulse then stimulates the liver to produce IGF-1, which mediates most of the downstream effects on body composition

This summary is followed by an overview of pattern recognition receptor (PRR)-mediated inflammatory responses, the pathogenesis of several representative inflammation-associated diseases, and existing anti-inflammatory therapies

Clinical pharmacology studies show tirzepatide has a half-life of approximately 5 days, allowing for once-weekly dosing with sustained therapeutic effects (Frias et al., Diabetes Care, 2021)

de Oliveira Francisco C, et al