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Cureus 15 , e37266 (2023)

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Cardiac protection via metabolic modulation: an emerging role for incretin-based therapies

Their use is rising rapidly, and with good reason: These medications have been shown to reduce blood sugar, improve fatty liver, GERD, sleep apnea, osteoarthritis, blood pressure, triglycerides, major adverse cardiovascular events, and even show potential benefits for conditions like alcohol use disorder (Mozaffarian et al., 2025

BFRs are also of concern due to their widespread occurrence in the environment and adverse effects on living organisms, including humans