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Genetic predispositions in GLP-1 pathway genes (GLP1R rs6923761, GIPR rs1800437, FTO rs9939609, MC4R rs17782313) may help contextualize expected medication response and guide dose selectionthough genetic testing does not replace clinical assessment or guarantee outcomes

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Joseph and receive an individualized plan that may include nutrition and lifestyle guidance, FDA-approved weight-management medications, metabolic testing or other appropriate treatment options

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In the STEP trials, semaglutide produced average weight loss of roughly 15 to 17% of body weight, while tirzepatide in the SURMOUNT trials reached approximately 20 to 22%