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f , Relative fold change of growth for Huh7 cells treated with indicated concentrations of R162 and -KG for 72 h

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The oxidative branch of the pentose phosphate pathway (PPP), driven primarily by the enzymes glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD), continues to serve as the dominant metabolic source of NADPH in most cells [42]

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It is also generally the first amino acid to be depleted