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Dual or triple-agonist needs: Patients who benefit from GIP co-agonism (tirzepatide) or who may need triple agonism (retatrutide, targeting GLP-1, GIP, and glucagon receptors) require injectable formulations that aren't currently available as oral small molecules

Uzawa, A., Oertel, F

This article examines the evidence, explores symptom management strategies, and clarifies when medical review is warranted for patients taking Mounjaro who suspect histamine intolerance

When a person exercises, the heart pumps faster to provide oxygen to the muscles, and vigorous/strenuous exercise, especially, can sometimes trigger heart palpitations, which is a good reason to get a doctors approval before starting an exercise program

Seuring T, Archangelidi O, Suhrcke M

Over time, as liver, adipose and skeletal muscle tissues develop a reduced insulin sensitivity, insulin secretion from pancreatic -cells is no longer suffice in maintaining blood glucose levels within the normal homeostatic range, resulting in hyperglycemia (Yamada et al., 2006)