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Cagrilintide is still investigational in the U.S

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Arapis, K

Safety data At least one treatment-emergent adverse event occurred in 86.4% of all participants, with a similar proportion of orforglipron participants experiencing an adverse event as placebo

However, within the TMD, the exendin-4 bound cavity is more open, predominantly due to a more outward location of TM1, however, TM2, TM4-ECL2-TM5 and TM7 are also located further from the centre of the bundle (Figure 3B)