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If proper titration starting at the lowest dose with gradual 4-week escalation still produces intolerable GI effects, split dosing may allow continued use of the medication rather than abandoning it entirely
Paclitaxel is the most commonly used drug across cancer types, especially in BC, prostate cancer and lung squamous cell carcinoma, and is often combined with chlorpromazine and carboplatin
On the basis of theoretical considerations, it was hypothesized that the operon encodes for a malic semialdehyde dehydrogenase (MSA-DH) which enables for the subsequent conversion of MSA into L-malate which might be channelled into the tricarboxylic acid cycle (Zhu et al., 2014)
Williams RM