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Liraglutide in clinical trials The clinical efficacy of once-daily liraglutide in patients with T2D was demonstrated in a study series entitled LEAD (Liraglutide Effect and Action in Diabetes)

Currently, several FDA-approved oral options have shown significant results in clinical trials when combined with lifestyle changes

Large randomized trials like SELECT (2024) showed that semaglutide reduced cardiovascular events by 18% in overweight or obese adults, despite rare thrombotic cases

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