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Indeed, increased E2 levels among overweight and obese postmenopausal women were due to the increased fat mass and E2 production in adipose tissue (Reference Gruber, Tschugguel and Schneeberger35)

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Dose, metabolism, disease model and outcome measures may not translate

By the subsequent action of CPT-I on the outer surface of the outer mitochondrial membrane, the carnitine carrier and CPT-II on the inner surface of the inner mitochondrial membrane, palmitoyl-CoA virtually is transported into the matrix, but note that its CoASH comes from the matrix space, while initially the CoASH is from the cytosol

Int J Mol Sci 2024;25:11363