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To the contrary, before and since the EPIC Study article was published in 2016, there have been numerous empirically researched studies which have found and concluded that species-wide echocardiographic parameters for distinguishing between normal and enlarged hearts do not exist and also that the healthy dogs of several breeds can have normal-sized hearts with dimensions significantly greater than the EPIC Study cut-off points, or truly enlarged hearts with dimensions significantly smaller than those cut-off points

Yeast also require either a functional TrxR1 or functional Gsr system for survival