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Other approaches to anti-sickling gene therapy in erythroid-specific lentiviral vectors include utilizing a -globin gene with three specific point mutations that confer anti-sickling properties (ClinicalTrials.gov Identifier: NCT02247843) or the introduction of a -globin coding sequence in a -globin gene to increase HbF levels and decrease HbS (ClinicalTrials.gov Identifier: NCT02186418) ( (b) Hb F induction: The well-established efficacy of increasing HbF has motivated both pharmacological and genetic approaches to HbF induction
Transmigration route of Campylobacter jejuni across polarized intestinal epithelial cells: paracellular, transcellular or both
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Ferroptosis has been implicated in a number of disorders such as neurodegenerative diseases (amyotrophic lateral sclerosis (ALS), Alzheimers disease (AD), Parkinsons disease (PD), and Huntingtons disease (HD), etc.), ischemia/reperfusion injury, and kidney degeneration
