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Its important to note that while NICE guidelines are influential, they are not legally binding

This represents the absolute maximum daily intake unlikely to cause adverse health effects, specifically benchmarked against the prevention of liver damage

The usual correction is further dilution, a higher ratio of acetic acid, or both, to disrupt the gel matrix and return the sample to a free-flowing liquid

Some patients benefit from injecting on the same day each week (for example, every Sunday evening) but at different times based on their scheduleflexibility within a weekly window is perfectly acceptable