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Tumor progression into soft tissues, lymph nodes or distant metastatic sites have been shown to dramatically reduce 5-year overall survival in patients with PTC, highlighting the need for a novel therapeutic approach for highly aggressive forms of PTC 6

In the brain, they are a major energy source and they provide acetyl-CoA for fatty acid synthesis, but they also support energy demand in oxidative organs, such as the heart and skeletal muscle, especially during exercise

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