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Intracellularly, mainly in adipose tissue, its antioxidant action is limited, thus uric acid could interact with other radicals, and this could initiate a cascade of reactions to generate superoxide forms

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There is a significant body of research, mostly from the 2000s, on the homocysteine-lowering benefits of B12 in patients with end-stage renal disease and who are on haemodialysis (HD), 80100% of whom have elevated homocysteine levels

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Cell 153 , 389401 (2013)