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Hormonal Imbalance Weight loss impacts hormone regulation, especially in women

Contraception Females QSYMIA can cause fetal harm when administered to a pregnant patient [see Use in Specific Populations (8.1)]

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As described in the same source, This is why the body needs to metabolise your muscles when youre in a calorie deficit. Early in a calorie deficit, the body first uses glycogen stores for energy

Excessive water retention Mild water retention represents a normal response to GH-active peptides

While many of these studies are based on animal models, early human trials and anecdotal reports suggest promising results