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However, the SPH domain lacks proteolytic activity due to a mutation of the catalytic residues

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Cagrilintide is modified with a fatty acid side chain to extend its half-life, enabling once-weekly administration in research settings

By eliminating these senescent cells, FOXO4-DRI alleviates the inflammatory microenvironment and shows potential to prevent the tumor-like aggressiveness and high recurrence rate characteristic of keloids