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Overall, treatment with semaglutide was associated with a reduction in the studys composite outcomecardiovascular death, nonfatal myocardial infarction or nonfatal strokeof 20% compared to a placebo, and it was linked to a safe and well-tolerated profile. SELECT trial results were published in the New England Journal of Medicine in November
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Fertility health: Support for preconception and pregnancy Fetal development: Ensures the proper development of the babys brain and spinal cord Cognitive function: Supports the myelin sheath, blood-brain-barrier function and neurotransmitter production The MTHFR gene, which instructs the body to produce the MTHFR enzyme, can sometimes undergo mutations
The results showed a consistent advantage for the combination, and that advantage became more pronounced at higher weight loss thresholds, precisely where GLP-1 therapy tends to be most clinically meaningful: At a 20% weight loss threshold, 45% of women in the combination group achieved this level of loss, compared to 24% in the GLP-1 alone group
Meaningful body composition changes typically become visible around weeks 8-12
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