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37 In addition, Zhang et al (2020) found that a single nucleotide polymorphism (SNP) in GLP-1R, rs2295006, was negatively associated with lumbar and total hip BMD in postmenopausal women, and similar observations have been made more recently by others

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Therefore, some of the benefits from GLP1RA therapy are likely to be secondary to the improvement in whole-body glucose metabolism through effects on the pancreas and adipose tissue control through effects on the central nervous system