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This study showed that pelvic irradiation can substantially promote pyknosis in the neurons of DG and CA2 regions of the hippocampus, which strongly supports that pelvic irradiation can cause memory and cognitive effects indirectly

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Together, these studies reveal substantial variability across antidiabetic drug classes and study types, suggesting that the observed neuroprotective effects are context-dependent and may arise through distinct molecular and metabolic mechanisms

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