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The specialist enzymatic antioxidant families include those that target hydrogen peroxide (H 2 O 2 ), which is the major redox signalling ROS reviewed by 5,24,25 , and those that target superoxide anion radical (O 2 - ) for the generation of H 2 O 2 as a product[reviewed by 26,27

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Frontiers in Pharmacology, 10 , 1172

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However, through several magnetic resonance spectroscopy studies (MRS) it has been shown that GSH levels are significantly decreased in the hippocampus, frontal, and cingulate cortices early in AD progression (Mandal et al., 2022)