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Most patients do not require discontinuation of therapy due to headaches alone

Se revis metdicamente la literatura de PubMed y MEDLINE desde 2000 hasta 2023

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These conditions include cardiovascular disease (such as coronary artery disease, stroke, life-threatening arrhythmias, congestive heart failure, or untreated hypertension), advanced arteriosclerosis, hyperthyroidism, glaucoma, psychiatric agitation or psychosis, recent or concurrent MAOI therapy (within 14 days), history of drug abuse, pregnancy, breastfeeding, pediatric patients under 16, and concurrent use of other weight-loss medications

2.1 Anti-chronic neuroinflammatory effects of EGCG Neuroinflammation serves as a protective mechanism within the nervous or central nervous system (CNS) against various threats including infections, toxic metabolites, autoimmunity, and traumatic brain injury, with the aim of eliminating harmful substances and damaged tissues (42)

By age 55, it drops to 25 g/kg/day (4)