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In addition, more than 40% of CagriSema-treated participants achieved weight loss of at least 25%, versus 6% of patients taking cagrilintide, 16.2% of those on semaglutide and 0.9% of participants in the placebo group

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12,21,22 The opening of the mitochondrial permeability transition pore under pathological conditions, such as oxidative stress, calcium overload, or energy depletion, leads to disruption of the mitochondrial membrane potential and the release of proapoptotic factors, ultimately culminating in cell death

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