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The combined interpretations from these studies support a model in which increased beta-cell GLP-1R signaling enhances alpha-cell GLP-1 production to amplify beta-cell function and insulin secretion through a local paracrine positive feedback loop of GLP-1 signaling ( Figure 5 )

Coursey TG, Henriksson JT, Marcano DC, Shin CS, Isenhart LC, Ahmed F, et al