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2ac) indicate that BAs, probably the FXR-antagonistic BAs, might contribute to the cell-nonautonomous regulation of GLP-1 production by T3

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Several studies indicate that a sustained weight loss of at least 10% of initial body weight improves several complications associated with obesity, including the prevention and control of type 2 diabetes, hypertension, fatty liver disease and sleep apnea

Body-Mass Index in 2.3 million adolescents and cardiovascular death in adulthood

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These options are intended for supervised use within a structured care model