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doi: 10.3390/ijms21041509

PMID 8110735

Pain syndromes caused by spinal disorders (lumbosciatica, plexopathy, radicular syndrome due to degenerative spinal changes)

As for the thyroid hormone and its receptor, there appears to be no reported direct interaction with the POMC promoter, although POMC -/- animals are known to display primary hyperthyroidism (34)