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Targeted delivery to peripheral nerves remains challenging due to the blood-nerve barrier, and off-target effects can pose safety risks
It inhibits prostaglandin synthesis by modulating cyclooxygenase (COX) enzyme activityespecially COX-2 and a central COX-3 variantresulting in analgesic and antipyretic effects
It also increases stress levels and makes it tougher to stick to a diet
When clinically appropriate, treatment plans may include advanced metabolic therapies, including GLP-1 based medications, as part of a comprehensive strategy
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