The correct guidance is: round to the nearest whole unit if your syringe lacks half-unit markings, but never round by more than 1 unit without provider approval
The clinical read-throughs are accumulating: a randomized trial (Hendershot et al., JAMA Psychiatry 2025) showed semaglutide cut drinks per drinking day, heavy drinking days, and cravings (and even cigarettes) versus placebo
Studies show a potential weight loss of up to 20% of total body weight within one year, compared to 7-10% achieved with traditional weight loss medications
In The High Costs of Low-Grade Inflammation, Dantzer points out that during chronic inflammation, insulin resistance in the brain decreases glucose and protein metabolism in the astrocytes, forcing the neurons to rely more heavily on the less efficient process of lipid metabolism for energy
Because of its very short half-life, native GLP-1 cannot be used for therapeutic purposes
It is widely used in topical anti-aging formulations for wrinkle reduction, skin firming, and improved complexion
