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At a standard dose of 300 micrograms per day, a 5mg vial lasts approximately 16 days

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From this perspective, MDR manifests biologically and clinically as four highly intertwined evolutionary subtypes: Firstly, de novo(primary) resistance, where tumors inherently harbor resistance mutations or exist in a profoundly immunosuppressed state, exhibiting absolute non-response from the initial treatment phase [14]

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For each sample, a standard 1D 1 H NMR spectrum was recorded using a CarrPurcellMeiboomGill (CPMG) spin-echo sequence to suppress water and broad protein signals

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