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The discoloration from medication typically appears as blue, brown, or black patches and may be widespread throughout the mouth

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Nature 477 , 9094 (2011)

This degradation, in turn, allows NF-B activity to increase, resulting in increased transcription of pro-inflammatory genes, including TNF-, IL-1, IL-6, and inducible nitric oxide synthase (iNOS) ( In addition to the NF-B pathway, the mitogen-activated protein kinase (MAPK) signaling cascade is also an important regulator of inflammatory responses in CNS microglia

Patient Preparation and Aftercare Before injection, patients should eat a light meal, hydrate well, and avoid vigorous physical activity

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