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When semaglutide is discontinued, gastric acid production, gastric emptying speed, and appetite all return toward baseline over several weeks

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Insulin resistance, hyperinsulinemia, dyslipidaemia, and obesity precede the progression to T2D in 7585 % of patients [65], and the presence of MetS increases up to fivefold the risk for T2D compared to individuals without MetS [66, 67]

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Its available as a research peptide or for investigational purposes under physician supervision