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A structural model of the interaction suggests that the active molecule is a hydrolyzed form of PL (hPL) which forms a complex with GSH in the enzyme active site

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Activation of LDHA by oncogenic receptor tyrosine kinase FGFR1 promotes glycolysis and tumor growth by increasing the NAD + /NADH ratio, 368 while the aberration of NAD + /NADH due to reduced activity of mitochondrial complex I promotes the aggressiveness of human breast cancer cells

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