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Furthermore, it mitigated the aggravating effects of L-NAME and L-arginine on convulsions, suggesting a potential non-NO-system involvement in its therapeutic effects

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however, several challenges still remain, especially the higher cost of a combined therapy and the worldwide underuse of either GLP-1RAs or SGLT2is in clinical practice, even in patients at high cardiorenal risk

Although melasma is a multifactorial skin disorder, however, sun-exposure and genetic predisposition are considered as the main etiologic factors in melasma occurrence

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