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Both routes are effective, but intramuscular injection into the target muscle theoretically enhances localized uptake due to proximity to upregulated receptors

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Treatment with an anti-CD226 monoclonal antibody reduced proliferation of CD4+ T cells and of CD8+ effector memory T cells in the spleen of female NOD mice, as well as the frequencies of autoreactive CD8+ T cells in the pancreas (96)

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