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GPER deficiency causes increased adiposity, insulin resistance, and metabolic dysfunction in mice (90)
The regulation of the VHLHIF pathway is also related to iron metabolism and ferroptosis in ccRCC, as iron levels are significantly higher in RCC cells and the tumor microenvironment than in normal renal tissue (77), and as HIF-1 mediates the cellular upregulation of TfRC and heme oxygenase (HO) expression, promoting cellular iron accumulation (78, 79)
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Eggermann, E., Kremer, Y., Crochet, S
Given the close connection between mitochondrial damage and oxidative stress [51, 52], the elevation of mitophagy could also indicate an escalation in the internal oxidative stress levels within the liver
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