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Common effects include: Nausea Constipation Vomiting Diarrhea Bloating Reduced appetite Less common but serious risks may include: Gallbladder disease Pancreatitis Severe dehydration Patients with certain thyroid cancer histories may not be appropriate candidates for some GLP-1 medications

Patients who may benefit most include: Adults with type 2 diabetes and hypertension This represents a common clinical scenario where metabolic and cardiovascular risk factors coexist

For example, an insulin that modifies its action based on current glucose levels would be a significant advance for everyone who uses insulin, not just those with type 1 diabetes

The comparison is personal, not absolute

One thing is certain: A large segment of our population needs help losing weight

A meta-analysis conducted in 20211 disclosed a reduction of allcause mortality by 12 percent