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Currently available pharmacotherapeutics options in HF mostly remain focused on HFrEF, where treatments strategies aim at relief of symptoms, improving quality of life, and prolonging the life of the affected individual (McDonagh et al., 2021

Mitochondrial -KG can then participate in the TCA cycle, supporting the oxidative phosphorylation (OXPHOS) pathway or the reductive carboxylation pathway 23

Experimental models continue to shed light on this complex relationship, albeit with contrasting findings

Targeting mitophagy, either through inhibition or promotion, represents a novel strategy for combination therapy in PDAC patients, potentially augmenting the efficacy of existing chemotherapy regimens