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Tesamorelin: The FDA-Approved Benchmark What sets tesamorelin apart Tesamorelin holds a unique position in the GH peptide landscape: it is the only GHRH analogue to receive FDA approval, granted in 2010 under the brand name Egrifta for the treatment of excess abdominal fat in HIV-infected adults with lipodystrophy a metabolic complication characterised by visceral fat accumulation and altered fat distribution

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Therefore, clonidine therapy must always be tapered gradually over a minimum of 2 to 4 days (or weeks for higher doses), and any concurrent beta-blockers must be discontinued several days prior to beginning the taper (JAVADIN, 2025