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In this context, persistent ROS accumulation can overwhelm antioxidant capacity and has been linked to caspase-dependent gasdermin cleavage in mammary cancer cells 186-189

Boh et al

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Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2) /System xc-/ glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis

Koltuksuz U, Uz E, Ozen S, et al

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