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Individuals with the following conditions face severe and life-threatening risks and should avoid coffee enemas : Digestive conditions, including Crohns disease, Ulcerative Colitis and Diverticulitis A history of bowel surgery Congestive heart failure Intestinal tumors Gastrointestinal cancer Blood vessel disease Kidney, heart, and liver disease Severe hemorrhoids Abdominal hernias Anemia Allergy to coffee Women who are pregnant or nursing should not undertake a coffee enema

Int J Cancer 2013

GPX-like proteins have been reported in many species, the importance of Sec has been recognized, and Sec-based glutathione peroxidase has been extensively studied in mammals, but they appear to play different roles in different locations or cells (Handy et al., 2021)