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But for those who've built up tolerance and want a clean, hard-hitting option, it delivers

Key takeaways Pairing a slight calorie restriction with increased physical activity to create a small-to-moderate calorie deficit can be a sustainable and effective way to lose weight

PMC 4854021

In fact, it can reduce cardiovascular risks in people with diabetes, insulin resistance, obesity, or heaviness with comorbid conditions

For patients who prefer pill-based treatments, or who struggle with injections, these findings represent important progress

Moreover, increases in testosterone, sex hormone-binding globulin (SHBG), and gonadotropin levels were also observed (73)