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It inhibits certain cytochrome P450 enzymes, which means it can increase blood levels of medications processed through those pathways

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Eur J Pharmacol (2013) 718(13):10513

doi: 10.1212/WNL.0000000000009569 198 RaberJ.WongD.YuG

A comprehensive meta-analysis of 27 clinical trials involving 2,569 patients demonstrated that berberine supplementation supports healthy blood sugar markers, including HbA1c, fasting glucose, and post-meal glucose levels, while also promoting insulin sensitivity

doi: 10.1046/j.1365-2133.2003.05303.x