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Additionally, GGCT mutants reversed this alteration, restoring [U- 13 C]-labeling of TCA metabolites and GSH

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doi: 10.1136/jitc-2022-004561 25 BonfantiALissoniPBucovecRRovelliFBrivioFFumagalliL

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They concluded that while GHK-Cu does demonstrate anti-wrinkle effects in cellular studies, "there is a surprising absence of clinical studies using them." The review identified skin permeation as the central challenge: GHK's high aqueous solubility and low partition coefficient work against transdermal absorption