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Der Komplex wurde erstmals in den 1970er-Jahren beschrieben und kommt im menschlichen Krper unter anderem im Blutplasma, Speichel und Urin vor

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studied 69 patients with IC/PBS (diagnosed based on the 1987 NIH criteria and including both ESSIC types 2 and 3) and 37 controls (with and without non-IC/BPS chronic cystitis) and demonstrated that the presence of mast cells correlated with the level of background lymphoplasmacytic infiltrate, but not with the diagnosis of IC

GHRP-6 and ghrelin both activate the same receptor (GHS-R1a)