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Both are weekly GLP-1 injections, but tirzepatide also acts on the GIP receptor and has generally produced greater average weight loss in trials

Linher-Melville K, Zantinge S, Sanli T, Gerstein H, Tsakiridis T, Singh G

Stone, An assessment of proposed mechanisms for sensing hydrogen peroxide in mammalian systems

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(54) Taken together, these studies suggest that protein intake may need to be reduced along with calories to lower IGF-1 levels

Certain clinical scenarios might warrant a more gradual approach to discontinuation, even though not pharmacologically necessary