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As yet, IUSCT has been performed on numerous human patients for various genetic disorders, notably osteogenesis imperfecta and alpha-thalassaemia (Le Blanc et al., 2005

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GS: data curation, project administration, resources, supervision, writing original draft, and writing review and editing

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Whilst the precise mechanism remains unclear, potential triggers include blood glucose fluctuations during treatment initiation, dehydration from gastrointestinal effects, and altered eating patterns

Sun D, Courtney HS, Beachey EH