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Clinical VitC monotherapy studies Clinical monotherapy studies administering high-dose VitC in patients with various types of advanced malignancies report this therapy to be safe, showing no significant toxicity at doses of up to 3 g/kg [13] (Table 2)

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This review integrates current evidence on how brain peptides contribute to AD pathophysiology, summarizes recent progress in peptide-based therapeutic strategies and delivery platforms, and critically examines the remaining barriers to clinical translation, including bloodbrain barrier penetration, metabolic stability, off-target effects, and the need for biomarker-guided patient stratification