Consistently with its low efficacy in beta-arrestin recruitment, which is involved in receptor endocytosis, the ability of tirzepatide to induce GLP-1R internalization is approximately 40% that of native GLP-1 while its effect on GIPR is similar to native GIP
Since the weight loss curves were non-linear (significant in the first year, then a plateau), longer protocols could have brought the figures closer together
Autonomic effects on salivary glands: Drugs that act on GLP-1 receptors can influence autonomic nervous system signals that control saliva production
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