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Furthermore, succinate has shown to regulate vascular tone 57

The mechanism involves upregulation of VEGF expression a key growth factor in new blood vessel formation and activation of ERK1/2 signaling pathways that drive cell proliferation, migration, and angiogenesis

Epalrestat protects against diabetic peripheral neuropathy by alleviating oxidative stress and inhibiting polyol pathway

2.12 Transcriptome sequencing and analysis USCs were seeded at a density of 2 10 4 cells/cm 2 in culture flasks, with three replicates per group

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Lower risks were also seen among people drinking one or two cups a day, with the association generally becoming stronger as consumption increased