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Furthermore, Cornu and colleagues found an autocrine loop where GLP-1 prevents the death of -cells in an IGF-1R-dependent manner via secretion of IGF-2 from the same cells (39)

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For researchers studying metabolic mechanisms, this triple-agonist approach also opens up research avenues that semaglutide cannot, particularly around glucagon-mediated energy expenditure and hepatic fat metabolism

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In high-fat diet-induced diabetes mice, administration of liraglutide activated pancreatic and duodenal homeobox-1 (Pdx-1), an essential regulator of proliferation and function of pancreatic -cells [56]

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These drugs were initially prescribed to treat Type 2 diabetes, but some are now approved for weight management in people age 12 or older

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If glucose is the star of our show, then insulin is the essential co-star

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