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The second assessment occurred at week 5, which included frailty status assessment, physical function, cognitive function, and nutritional status
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4 Current therapeutic landscape and unmet need While resmetirom (a THR- agonist) has recently gained FDA approval for the treatment of MASH (in patients with fibrosis F2-F3), marking the first-ever pharmacological agent for this condition (Liu et al., 2025), there remains no single FDA-approved drug that effectively prevents or reverses the progression of advanced SLD to HCC
doi: 10.1016/0006-8993(86)90769-9 76
Retatrutide vs Semaglutide (Ozempic): 28.7% vs 15% (2026 Data) Triple vs single agonist mechanisms, safety, availability
[PubMed: 20520602] 95
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